A prospective study of corpus callosum regional volumes and neurocognitive outcomes following cranial radiation for pediatric brain tumors.
Arif RashidAshwin N RamWendy R KatesKristin J RedmondMoody WharamE Mark MahoneAlena HorskaStephanie Alicia TerezakisPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2017)
These prospective data demonstrate a significant decrease in CC regional volumes after CRT, with associated decline in neurocognitive function, most notably in manual dexterity, attention, and working memory. Further prospective study of larger cohorts of patients is needed to establish the relationship between CRT dose, neuroanatomical, and functional changes in the CC.