Mass spectrometry-based retina proteomics.
Laszlo ProkaiKhadiza ZamanKatalin Prokai-TatraiPublished in: Mass spectrometry reviews (2022)
A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry's contributions to facilitate mammalian and avian retina proteomics to catalog and quantify retinal protein expressions, determine their posttranslational modifications, as well as its applications to study the proteome of the retina in the context of biology, health and diseases, and therapy developments.
Keyphrases
- mass spectrometry
- diabetic retinopathy
- optic nerve
- liquid chromatography
- capillary electrophoresis
- high performance liquid chromatography
- gas chromatography
- optical coherence tomography
- high resolution
- healthcare
- public health
- label free
- mental health
- binding protein
- single molecule
- amino acid
- cell therapy
- bone marrow
- small molecule
- smoking cessation