Biocompatible hydroxyapatite-based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem cells.

Pranjita Zantye Asha Dahiya Meenal Kowshik Sutapa Roy Ramanan Indrani Talukdar

Published in: The journal of gene medicine (2024)

The results demonstrate that R8HNPs are promising, biocompatible, non-viral alternatives for prolonged gene silencing and obtaining differentiated cells for therapeutics.

Keyphrases

embryonic stem cells
sars cov
induced apoptosis
ionic liquid
cell cycle arrest
drug release
genome wide
small molecule
signaling pathway
cell death
drug delivery
gene expression
bone regeneration
cell proliferation
tissue engineering