Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases.

He-Fen SunLiang-Dong LiI-Weng LaoXuan LiBao-Jin XuYi-Qun CaoWei Jin

Published in: Clinical and translational medicine (2022)

Our findings provide a comprehensive understanding of the heterogenicity of the tumor microenvironment and tumour cells and it will be crucial for successful immunotherapy development for brain metastasis of lung cancer.

Keyphrases

single cell
brain metastases
rna seq
small cell lung cancer
induced apoptosis
high throughput
cell cycle arrest
high grade
resting state
oxidative stress
cell death
cerebral ischemia
single molecule
multiple sclerosis
cell proliferation
pi k akt
blood brain barrier