Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.

Mulong DuJoe G N GarciaJason D ChristieJunyi XinGuoshuai CaiNuala J MeyerZhaozhong ZhuQianyu YuanZhengdong ZhangLi SuSipeng ShenXuesi DongHui LiJohn N HutchinsonPaula TejeraXihong LinMeilin WangFeng ChenDavid Chistopher Christiani

Published in: Intensive care medicine (2021)

Our findings suggest a novel susceptibility locus in ARDS pathophysiology that implicates BORCS5 and DUSP16 as potentially acting in immune-inflammatory processes. This locus warrants further investigation to inform the development of therapeutic targets and clinical care strategies for ARDS, including those induced by COVID-19.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
coronavirus disease
healthcare
sars cov
palliative care
oxidative stress
quality improvement
intensive care unit
single cell
chronic pain
health insurance