Serum osmolality, cerebrospinal fluid specific gravity and overt hepatic encephalopathy severity in patients with liver failure.
Eric M LiottaConstantine J KarvellasMinjee KimAyush BatraAndrew NaidechShyam PrabhakaranFarzaneh A SorondW Taylor KimberlyMatthew B MaasPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
In the context of related research, these data suggest that hyperosmolality increases brain exposure to metabolic toxins by blood-brain barrier alteration and may be a unique therapeutic target.