Magnetic and injectable Fe-doped liquid metals for controlled movement and photothermal/electromagnetic therapy.
Yingjie CaoLinlin FanJianye GaoXiyu ZhuBingjie WuHongzhang WangBo WangJun ShiJing LiuPublished in: Journal of materials chemistry. B (2024)
As a multifunctional material, gallium-based liquid metal (LM) mixtures with metal particles dispersed in the LM environment display many excellent and intriguing properties. In this study, biomaterials were prepared by mixing Fe particles with LM for easily manageable photothermal or electromagnetic therapy and evaluated. Clinically, the fabricated 5%Fe/LM sample was injectable and radiopaque, which allowed its smooth delivery through a syringe to the target tissues, where it could help achieve clear imaging under CT. Meanwhile, because of the loading of Fe particles, the 5%Fe/LM possessed a magnetic property, implying a high manipulation capability. According to the experiments, the capsule containing 5%Fe/LM when placed in an isolated pig large intestine could move as desired to the designated position through an external magnet. Further, the biosafety and low toxicity of the 5%Fe/LM were confirmed by cytotoxicity tests in vitro , and the temperature changes at the interface between the 5%Fe/LM and intestinal tissue after near-infrared (NIR) laser irradiation were determined through theoretical modeling and numerical simulation data analysis. Due to the excellent photothermal and magnetothermal effects of LM, the temperature of the 5%Fe/LM injected into the rabbit abdominal cavity could significantly increase under NIR laser or alternating magnetic field (AMF) administration. As a novel functional biomaterial, the 5%Fe/LM exhibited promising potential for designated position movement and photothermal or magnetothermal therapy in the near future.
Keyphrases
- metal organic framework
- photodynamic therapy
- drug delivery
- cancer therapy
- aqueous solution
- drug release
- visible light
- data analysis
- magnetic resonance imaging
- gene expression
- oxidative stress
- high resolution
- ionic liquid
- computed tomography
- radiation therapy
- mesenchymal stem cells
- bone marrow
- mass spectrometry
- climate change
- smoking cessation
- health risk
- liquid chromatography
- virtual reality
- health risk assessment