Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells.

Man-Yuan LiJiao ZhangXiao LuDong ZhouXu-Feng DengQuan-Xing LiuJi-Gang DaiHong Zheng

Published in: Cancer chemotherapy and pharmacology (2023)

This study not only revealed the mechanism of ivermectin inhibited the growth of LUAD but also supported an important theoretical basis for the development of ivermectin during the therapy for LUAD.

Keyphrases

cell cycle arrest
endoplasmic reticulum stress
induced apoptosis
cell death
oxidative stress
drug administration
signaling pathway
pi k akt
single cell