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Ring-fused hexahydro-1,2,4,5-tetrazines: synthesis, structure, and mechanistic studies on isolable rotational isomers.

Yasunori TodaAiri KooguchiKimiya SukegawaAyaka KikuchiHiroyuki Suga
Published in: Chemical communications (Cambridge, England) (2022)
We designed conformationally stable rotational isomers around the C(sp 2 )-C(sp 3 ) axis at the C 3 -position of hexahydro-1,2,4,5-tetrazines. Isolation of each rotamer by silica gel column chromatography was successfully achieved at room temperature. The proposed isomerization mechanism of the rotamers was supported by NMR kinetic studies.
Keyphrases
  • room temperature
  • case control
  • liquid chromatography
  • mass spectrometry
  • ionic liquid
  • magnetic resonance
  • high resolution
  • high speed
  • tandem mass spectrometry
  • hyaluronic acid
  • simultaneous determination