Chiral Recognition and Resolution of Phosphoric Acids Using Octahedral Cobalt Complexes.

Determining the chirality of phosphoric acids can be a challenging task. In this study, we present a novel approach for the chiral recognition of phosphates using cationic octahedral cobalt complexes. By utilizing 31 P NMR spectroscopy, we are able to accurately measure the enantiopurities of chiral phosphoric acids after forming ion pairs with the cobalt complexes. We have successfully applied this method to a variety of chiral phosphoric acids derived from BINOL, H8-BINOL, SPINOL, VAPOL, and VANOL compounds, as well as ATP, and were able to efficiently resolve them in 31 P{ 1 H} NMR spectra. Furthermore, we were able to achieve an optical resolution of a phosphoric acid with an enantiomeric excess of greater than 99%.