A novel tissue-based ß-catenin gene and immunohistochemical analysis to exclude familial adenomatous polyposis among children with hepatoblastoma tumors.

Hendrikus J DubbinkIris H I M HollinkCarolina Avenca ValenteWenhui WangPengyu LiuMichail DoukasMax M van NoeselWinand N M DinjensAnja WagnerRon Smits

Published in: Pediatric blood & cancer (2018)

We have successfully established and validated a novel ß-catenin gene and immunohistochemical diagnostic method, which, when combined with routine germline DNA testing, allows the exclusion of the diagnosis of FAP among HB patients.

Keyphrases

end stage renal disease
epithelial mesenchymal transition
ejection fraction
cell proliferation
copy number
newly diagnosed
genome wide
chronic kidney disease
peritoneal dialysis
circulating tumor
gene expression
single molecule
dna repair
cell free
signaling pathway
patient reported