Single Doping for Triple Functions: Integrated Theranostic Nanoplatforms for Multimodal Image-Guided Tumor Therapy.

Accurate location and efficient treatment of diseases by multifunctional nanoplatforms is appealing but faces great challenges. Theranostic agents through the physical combination of different functional nanoparticles (NPs) have demonstrated to be effective. Yet, the complicated biological environment often leads to ambiguous fates of each agent, which fails to keep the behaviors of imaging and therapeutic components in a simultaneous manner. Herein, we have constructed "integrated" theranostic NPs, Gd-doped CuWO 4 (CWG) with strong near-infrared (808 nm) absorption, the longest absorption peak of reported CuWO 4 , located in biological transparent window. The single doping of trace amount of Gd not only endowed them with a distinguished magnetic resonance imaging (MRI) capability (r 1 = 12.01 mM -1 s -1 ), but also concurrently imposed great effect on the valence states of matrix ion (Cu), as evidenced by theoretical calculation results. The charge distribution shift of Cu would facilitate ⚫OH generation, beneficial for chemodynamic therapy (CDT). Moreover, CWG NPs displayed remarkable photoacoustic (PA) and computed tomography (CT) imaging capabilities (S = 10.33 HU mM -1 ). Such integrated theranostics afforded a paradigm for multimodal imaging (MRI/CT/PA) guided synergistic therapy (PTT/CDT) with all-in-one single nanoparticle. This article is protected by copyright. All rights reserved.