Mechanical circulatory support in cardiogenic shock.
Jun NakataTakeshi YamamotoKeita SakuYuki IkedaTakashi UnokiKuniya AsaiPublished in: Journal of intensive care (2023)
Cardiogenic shock is a complex and diverse pathological condition characterized by reduced myocardial contractility. The goal of treatment of cardiogenic shock is to improve abnormal hemodynamics and maintain adequate tissue perfusion in organs. If hypotension and insufficient tissue perfusion persist despite initial therapy, temporary mechanical circulatory support (t-MCS) should be initiated. This decade sees the beginning of a new era of cardiogenic shock management using t-MCS through the accumulated experience with use of intra-aortic balloon pump (IABP) and venoarterial extracorporeal membrane oxygenation (VA-ECMO), as well as new revolutionary devices or systems such as transvalvular axial flow pump (Impella) and a combination of VA-ECMO and Impella (ECPELLA) based on the knowledge of circulatory physiology. In this transitional period, we outline the approach to the management of cardiogenic shock by t-MCS. The management strategy involves carefully selecting one or a combination of the t-MCS devices, taking into account the characteristics of each device and the specific pathological condition. This selection is guided by monitoring of hemodynamics, classification of shock stage, risk stratification, and coordinated management by the multidisciplinary shock team.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- respiratory failure
- healthcare
- machine learning
- deep learning
- mechanical ventilation
- aortic valve
- magnetic resonance imaging
- magnetic resonance
- quality improvement
- pulmonary hypertension
- atrial fibrillation
- contrast enhanced
- bone marrow
- smooth muscle
- heart failure
- mesenchymal stem cells
- combination therapy
- replacement therapy