Pro-resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates.

Mai E Nguyen-ChiPatricia Luz-CrawfordLaurence BalasTamara SipkaRafael Contreras-LópezAudrey BarthelaixGeorges LutfallaThierry DurandChristian JorgensenFarida Djouad

Published in: British journal of pharmacology (2020)

These results reveal the pro-regenerative action of PD1 and its role in regulating neutrophil and macrophage response in vertebrates. These findings strongly support the development of pro-resolving mediators as natural therapeutic candidates for degenerative disorders and the use of the zebrafish as a tool to investigate pro-regenerative drugs.

Keyphrases

stem cells
anti inflammatory
mesenchymal stem cells
cell therapy
adipose tissue
tissue engineering
gene expression
wound healing