CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection.

Yanshan JiangFan LiYanan LiJielin DuanCaixia DiYinggang ZhuJingya ZhaoXinming JiaJie-Ming Qu

Published in: Clinical and translational medicine (2022)

CD69 recognizes P. aeruginosa and further facilitates ERK1 activation, which plays a crucial role in ASCs-based therapy against P. aeruginosa pneumonia. CD69 may be a novel target molecule to improve ASCs-based therapy against P. aeruginosa infection.

Keyphrases

adipose tissue
pseudomonas aeruginosa
nk cells
signaling pathway
cell proliferation
pulmonary hypertension
insulin resistance
stem cells
high fat diet
type diabetes
metabolic syndrome
pi k akt
mesenchymal stem cells
skeletal muscle
acinetobacter baumannii
extracorporeal membrane oxygenation
mechanical ventilation