Atrial Myopathy Quantified by Speckle-Tracking Echocardiography in Mice.
Michael J ZhangDylan J GybergChastity L HealyNaixin ZhangHong LiuSamuel C DudleyTimothy D O'ConnellPublished in: Circulation. Cardiovascular imaging (2023)
Using speckle-tracking echocardiography, we observed reduced LA function in established mouse models of atrial myopathy with concurrent atrial fibrillation inducibility, thus providing the field with a timely and clinically relevant platform for understanding the pathophysiology and discovery of novel treatment targets for atrial myopathy.
Keyphrases
- atrial fibrillation
- left atrial
- catheter ablation
- late onset
- left ventricular
- oral anticoagulants
- left atrial appendage
- muscular dystrophy
- high throughput
- pulmonary hypertension
- computed tomography
- direct oral anticoagulants
- mouse model
- heart failure
- small molecule
- mitral valve
- percutaneous coronary intervention
- early onset
- locally advanced
- high fat diet induced
- venous thromboembolism
- squamous cell carcinoma
- combination therapy
- radiation therapy
- skeletal muscle
- rectal cancer
- wild type