Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid.
Anna BatesonJulio Ortiz CansecoTimothy D McHughAdam A WitneySilke FeuerriegelMatthias MerkerThomas A KohlChristian UtpatelStefan NiemannSönke AndresKatharina KranzerFlorian P MaurerArash GhodousiEmanuele BorroniDaniela Maria CirilloMaria WijkanderJuan C ToroRamona GroenheitJim WerngrenDiana MachadoMiguel ViveirosRobin M WarrenFrederick SirgelAnzaan DippenaarClaudio Umberto KöserEugene SunJuliano TimmPublished in: The Journal of antimicrobial chemotherapy (2022)
In light of these findings, the provisional critical concentration of 1 mg/L for MGIT set by EMA must be re-evaluated. More broadly, these findings underline the importance of considering the global diversity of MTBC during clinical development of drugs and when defining breakpoints for AST.