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Inhibition of RNase 7 by RNase inhibitor promotes inflammation and Staphylococcus aureus growth: Implications for atopic dermatitis.

Franziska RademacherAnnika ScheelRegine GläserLena SchröderNina HeinemannJoachim BartelsSascha GerdesDora StölzlElke RodriguezKatinka DöhnerStephan WeidingerThomas WerfelJürgen Harder
Published in: Allergy (2024)
Our data suggest a novel role of RI as a trigger factor of inflammation in AD by blocking the ribonuclease and antimicrobial activity of RNase 7, thereby enhancing RNA-mediated inflammation and S. aureus growth.
Keyphrases
  • oxidative stress
  • staphylococcus aureus
  • atopic dermatitis
  • electronic health record
  • pseudomonas aeruginosa
  • biofilm formation
  • cystic fibrosis
  • nucleic acid
  • candida albicans