Inhibition of RNase 7 by RNase inhibitor promotes inflammation and Staphylococcus aureus growth: Implications for atopic dermatitis.
Franziska RademacherAnnika ScheelRegine GläserLena SchröderNina HeinemannJoachim BartelsSascha GerdesDora StölzlElke RodriguezKatinka DöhnerStephan WeidingerThomas WerfelJürgen HarderPublished in: Allergy (2024)
Our data suggest a novel role of RI as a trigger factor of inflammation in AD by blocking the ribonuclease and antimicrobial activity of RNase 7, thereby enhancing RNA-mediated inflammation and S. aureus growth.