NF-kB-dependent activation of STAT3 by H. pylori is suppressed by TFF1.

Mohammed SouttoNadeem BhatShayan KhalafiShoumin ZhuJulio PovedaMonica Garcia-BuitragoAlexander ZaikaWael El-Rifai

Published in: Cancer cell international (2021)

Our findings suggest the presence of an early autocrine NF-kB-dependent activation of STAT3 in response to H. pylori infection. TFF1 acts as an anti-inflammatory guard against H. pylori-mediated activation of pro-inflammatory networks.

Keyphrases

signaling pathway
anti inflammatory
lps induced
oxidative stress
pi k akt
immune response