METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets.

Kai-Wen HsuJoseph Chieh-Yu LaiJeng-Shou ChangPei-Hua PengChing-Hui HuangDer-Yen LeeYu-Cheng TsaiChi-Jung ChungHan ChangChao-Hsiang ChangJi-Lin ChenSee-Tong PangZiyang HaoXiao-Long CuiChuan HeHan-Tsang Wu

Published in: Genome biology (2022)

We show that hypoxia results in enriched 6mA levels in mammalian tumor cells through METTL4. This METTL4-mediated nuclear 6mA deposition induces tumor metastasis through activating multiple metastasis-inducing genes. METTL4 is characterized as a potential therapeutic target in hypoxic tumors.

Keyphrases

signaling pathway
genome wide
dna methylation
endothelial cells
risk assessment
transcription factor
climate change
bioinformatics analysis