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Disruption of LTBP4 Induced Activated TGFβ1, Immunosuppression Signal and Promoted Pulmonary Metastasis in Hepatocellular Carcinoma.

Xiou YangXiaojuan YeLiuyan ZhangXingguo ZhangPeng Shu
Published in: OncoTargets and therapy (2020)
Our results demonstrate that the LTBP4-TGFβ1-MDSCs axis is a critical pathway for the immune suppression signals of HCC primary tumors.
Keyphrases
  • transforming growth factor
  • high glucose
  • pulmonary hypertension
  • diabetic rats
  • epithelial mesenchymal transition
  • drug induced
  • endothelial cells
  • signaling pathway