25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.

Man Ying WongMichael LewisJames J DohertyYang ShiAnil G CashikarAnna AmelianchikSvitlana TymchukPatrick M SullivanMingxing QianDouglas F CoveyGregory A PetskoDavid M HoltzmanSteven M PaulWenjie Luo

Published in: Journal of neuroinflammation (2020)

25-HC may function as a microglial-secreted inflammatory mediator in the brain, promoting IL-1β-mediated neuroinflammation in an apoE isoform-dependent manner (E4>>E2/E3) and thus may be an important mediator of neuroinflammation in AD.

Keyphrases

lipopolysaccharide induced
lps induced
inflammatory response
cognitive decline
cerebral ischemia
high fat diet
traumatic brain injury
neuropathic pain
cognitive impairment
oxidative stress
spinal cord injury
metabolic syndrome