Effects of Cardiac Hypertrophy, Diabetes, Aging, and Pregnancy on the Cardioprotective Effects of Postconditioning in Male and Female Rats.

Fawzi A Babiker Aishah Al-JarallahMariam Al-Awadi

Published in: Cardiology research and practice (2019)

We demonstrate that aging, LVH, diabetes mellitus, and pregnancy do not affect cardiac vulnerability to ischemic insult. Moreover, PPC mediates cardioprotection in a gender-specific manner in aged and spontaneously hypertensive rats. Diabetes mellitus provokes the protective effects of PPC on both genders equally. Finally, we demonstrate that PPC is a new cardioprotective maneuver in hearts from pregnant female rats.

Keyphrases

glycemic control
preterm birth
type diabetes
pregnancy outcomes
ischemia reperfusion injury
cardiovascular disease
pregnant women
cerebral ischemia
climate change
left ventricular
heart failure
oxidative stress
weight loss
atrial fibrillation
blood brain barrier
subarachnoid hemorrhage