Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3.

Takashi ItoMayumi NakaharaYoshiki MasudaSachie OnoShingo YamadaHiroyasu IshikuraHitoshi ImaizumiChinatsu KamikokuryoYasuyuki KakihanaIkuro Maruyama

Published in: Journal of intensive care (2018)

Our novel ELISA provides reproducible measurements of histone H3 levels. Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner. Further studies are needed to evaluate the clinical utility of histone H3 levels in patients with sepsis.

Keyphrases

acute kidney injury
high fat diet induced
intensive care unit
type diabetes
adipose tissue
cell therapy
insulin resistance
septic shock