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Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling.

Lars GodmannMiriam BollmannAdelheid Korb-PapUlrich KönigJoanna SherwoodDenise BeckmannKatja MühlenbergFrank EchtermeyerJames WhitefordGiulia De RossiThomas PapJessica Bertrand
Published in: Annals of the rheumatic diseases (2020)
Collectively, our data suggest that Ab that specifically inhibit sdc4 dimerisation may support anti-IL-1 strategies in diseases such as inflammatory arthritis.
Keyphrases
  • rheumatoid arthritis
  • electronic health record
  • oxidative stress
  • machine learning