NF-κB-Signaling-Targeted Immunomodulatory Nanoparticle with Photothermal and Quorum-Sensing Inhibition Effects for Efficient Healing of Biofilm-Infected Wounds.
Sezhen QuniYidi ZhangLijun LiuManxuan LiuLu ZhangJiaqian YouJing CuiXiuyu LiuHanchi WangDaowei LiYanmin ZhouPublished in: ACS applied materials & interfaces (2024)
The development of therapeutics with high antimicrobial activity and immunomodulatory effects is urgently needed for the treatment of infected wounds due to the increasing danger posed by recalcitrant-infected wounds. In this study, we developed light-controlled antibacterial, photothermal, and immunomodulatory biomimetic N/hPDA@M nanoparticles (NPs). This nanoplatform was developed by loading flavonoid naringenin onto hollow mesoporous polydopamine NPs in a π-π-stacked configuration and encasing them with macrophage membranes. First, our N/hPDA@M NPs efficiently neutralized inflammatory factors present within the wound microenvironment by the integration of macrophage membranes. Afterward, the N/hPDA@M NPs effectively dismantled bacterial biofilms through a combination of the photothermal properties of PDA and the quorum sensing inhibitory effects of naringenin. It is worth noting that N/hPDA@M NPs near-infrared-enhanced release of naringenin exhibited specificity toward the NF-κB-signaling pathway, effectively mitigating the inflammatory response. This innovative design not only conferred remarkable antibacterial properties upon the N/hPDA@M NPs but also endowed them with the capacity to modulate inflammatory responses, curbing excessive inflammation and steering macrophage polarization toward the M2 phenotype. As a result, this multifaceted approach significantly contributes to expediting the healing process of infected skin wounds.
Keyphrases
- signaling pathway
- cancer therapy
- wound healing
- photodynamic therapy
- inflammatory response
- oxide nanoparticles
- oxidative stress
- drug release
- lps induced
- pi k akt
- drug delivery
- adipose tissue
- candida albicans
- small molecule
- epithelial mesenchymal transition
- staphylococcus aureus
- stem cells
- induced apoptosis
- lipopolysaccharide induced
- escherichia coli
- physical activity
- toll like receptor
- endoplasmic reticulum stress
- molecularly imprinted
- combination therapy