Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching.
Xiaoyang YueJunping YinXiaoqing WangHarald HeideckeAlexander Maximilian HackelXiaoru DongBrigitte KasperLifang WenLiang ZhangKai Schulze-ForsterJuliane JunkerHanna GrasshoffAntje MüllerGerd WallukatIngolf SchimkeJulian ZeinerLisa Marie DecksteinNicole MertensAnja Kerstein-StaehleJennifer Elisabeth HundtEvi KostenisXinhua YuGabriela RiemekastenFrank PetersenPublished in: Annals of the rheumatic diseases (2022)
Our immunisation strategy successfully induced AT1R Abs, contributing to inflammation and, possibly, to fibrosis via activation of AT1R. Therefore, AT1R Abs are valuable targets for future therapies of SSc and other AT1R Ab-related diseases.