Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma.

Gwendolen LorchKarthigayini SivaprakasamVictoria ZismannNieves PerdigonesTania Contente-CuomoAlexandra NazarenoSalvatore FacistaShukmei WongKevin DrennerWinnie S LiangJoseph M AmannSara L Sinicropi-YaoMichael J KoenigKrista La PerleTimothy G WhitsettMuhammed MurtazaJeffrey M TrentDavid P CarboneWilliam P D Hendricks

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

This study creates a foundation for molecular understanding of and drug development for canine lung cancer. These data also establish molecular contexts for comparative studies in dogs and humans of low mutation burden, never-smoker lung cancer, and mutant HER2 function and inhibition.

Keyphrases

squamous cell carcinoma
pulmonary hypertension
signaling pathway
electronic health record
big data
radiation therapy
risk factors
machine learning
artificial intelligence
wild type
bioinformatics analysis
data analysis
rectal cancer