A precise molecular subtyping of ulcerative colitis reveals the immune heterogeneity and predicts clinical drug responses.

Shaocong MoBryan JinYujen TsengLingxi LinLishuang LinXin ShenHuan SongMingjia KongZhongguang LuoYiwei ChuChen JiangZhiwei CaoJie LiuFeifei Luo

Published in: Journal of translational medicine (2023)

We identified three stable UC subtypes with a heterogeneous immune pattern and different response rates towards biological agents for the first time. We also established a precise molecular subtyping system and classifier to predict clinical drug response and provide individualized treatment strategies for UC patients.

Keyphrases

end stage renal disease
ulcerative colitis
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
emergency department
electronic health record