Preemptive iron supplementation prevents myocardial iron deficiency and attenuates adverse remodelling after myocardial infarction.

We demonstrate, for the first time, that dynamic changes in cardiac iron status after MI are associated with local hepcidin suppression, leading to cardiac ID long-term after MI. Preemptive iron supplementation maintained cardiac iron content and attenuated adverse remodelling after MI. Our results identify the spontaneous development of cardiac ID as a novel disease mechanism and therapeutic target in postinfarction LV remodelling and HF.