Glutamate is an essential mediator in glutamine-amplified insulin secretion.
Guirong HanHarumi TakahashiNaoya MuraoGhupurjan GheniNorihide YokoiYoshiyuki HamamotoShun-Ichiro AsaharaYutaka SeinoYoshiaki KidoSusumu SeinoPublished in: Journal of diabetes investigation (2021)
Glutamate converted from glutamine is an essential mediator that enhances calcium signaling in the glutamine-amplifying effect on insulin secretion. Our data also suggest that glutamine exerts a permissive effect on glucose-induced insulin secretion.