Structures and biological activities of cycloheptamycins A and B.
Zhengyi QianJanine AntoschJutta WieseJohannes F ImhoffHans-Peter FiedlerAlexander PöthigTobias A M GulderPublished in: Organic & biomolecular chemistry (2019)
The heptadepsipeptide cycloheptamycin A was isolated from the terrestrial Streptomyces sp. Tü 6314. Its constitution was elucidated on the basis of NMR spectroscopic experiments and mass spectrometric analysis. Its stereostructure was investigated by peptide hydrolysis and derivatization and firmly established by X-ray structure analysis. In addition to the parent compound, a new cycloheptamycin analog, cycloheptamycin B, was discovered and structurally assigned using comparative MS/MS experiments and NMR. The biological profile of both compounds was investigated, revealing a selective inhibitory potential of cycloheptamycins against Propionibacterium acnes.
Keyphrases
- ms ms
- high resolution
- magnetic resonance
- liquid chromatography tandem mass spectrometry
- computed tomography
- molecular docking
- solid state
- magnetic resonance imaging
- mass spectrometry
- risk assessment
- high performance liquid chromatography
- gas chromatography mass spectrometry
- contrast enhanced
- dual energy
- data analysis
- solid phase extraction
- electron microscopy