Systemic dissemination of glioblastoma: literature review.
Juliana Arcangelo Di Vita CarvalhoCaroline Chaul de Lima BarbosaOlavo FeherMarcos Vinicius Calfat MaldaunVeridiana Pires de CamargoFabio Ynoe de MoraesGustavo Nader MartaPublished in: Revista da Associacao Medica Brasileira (1992) (2019)
Tumor cells must overcome many obstacles until the development of systemic metastasis. The physiologic mechanisms are not completely clear. Although not fully understood, the pathophysiological understanding of the mechanisms that may be associated with the systemic spread is salutary for a global understanding of the disease. In addition, this knowledge may be used as a basis for a therapy to be performed in patients diagnosed with GBM distant metastasis.