Radioguided surgery with β radiation: a novel application with Ga68.
Francesco CollamatiValerio BocciPaolo CastellucciMicol De SimoniStefano FantiRiccardo FacciniAlessandro GiordanoDaria MaccoraCarlo Mancini-TerraccianoMichela MarafiniRiccardo MirabelliSilvio MorgantiRiccardo SchiavinaTeresa ScotognellaGiacomo TrainiElena Solfaroli CamillocciPublished in: Scientific reports (2018)
Radio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting probes. The efficacy of this technique is however hindered by the high penetration of γ radiation, limiting its applicability to low background conditions. To overtake such limitations, a novel approach to RGS has been proposed, relying on β- emitting isotopes together with a dedicated β probe. This technique has been proved to be effective in first ex-vivo trials. We discuss in this paper the possibility to extend its application cases to 68Ga, a β+ emitting isotope widely used today in nuclear medicine. To this aim, a retrospective study on 45 prostatic cancer patients was performed, analysing their 68Ga-PSMA PET images to asses if the molecule uptake is enough to apply this technique. Despite the expected variability both in terms of SUV (median 4.1, IQR 3.0-6.1) and TNR (median 9.4, IQR 5.2-14.6), the majority of cases have been found to be compatible with β-RGS with reasonable injected activity and probing time (5 s).
Keyphrases
- pet ct
- minimally invasive
- coronary artery bypass
- quantum dots
- positron emission tomography
- fluorescent probe
- living cells
- robot assisted
- surgical site infection
- pet imaging
- small molecule
- radiation induced
- prostate cancer
- computed tomography
- deep learning
- percutaneous coronary intervention
- molecular dynamics simulations
- magnetic resonance imaging
- convolutional neural network
- energy transfer
- acute coronary syndrome
- mass spectrometry
- atrial fibrillation
- light emitting
- photodynamic therapy
- solid phase extraction
- gas chromatography