Patient-reported outcomes and neurotoxicity markers in patients treated with bispecific LV20.19 CAR T cell therapy.

Jennifer Mary KnightAniko SzaboIgli ArapiRuizhe WuAmanda EmmrichEdward HackettGarrett SauberSharon YimBryon JohnsonParameswaran N HariDina SchneiderBoro DropulicRachel N CusatisSteve W ColeCecilia J Hillard Nirav N Shah

Published in: Communications medicine (2022)

Elevated levels of kynurenine pathway metabolites among CAR T cell recipients are associated with depressed mood and neurotoxicity. Findings from this exploratory study are preliminary and warrant validation in a larger cohort.

Keyphrases

cell therapy
patient reported outcomes
stem cells
mesenchymal stem cells
bipolar disorder
ms ms
bone marrow
kidney transplantation