Local Anesthetic Like Inhibition of the Cardiac Na + Channel Nav1.5 by Chloroquine and Hydroxychloroquine.
Axel HageMathis de VriesAndreas LefflerCarsten StoetzerPublished in: Journal of experimental pharmacology (2022)
This study demonstrated that CQ and HCQ exert LA-typical effects on Nav1.5 involving the proposed LA binding site, thus contributing to their arrhythmogenic properties.