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Local Anesthetic Like Inhibition of the Cardiac Na + Channel Nav1.5 by Chloroquine and Hydroxychloroquine.

Axel HageMathis de VriesAndreas LefflerCarsten Stoetzer
Published in: Journal of experimental pharmacology (2022)
This study demonstrated that CQ and HCQ exert LA-typical effects on Nav1.5 involving the proposed LA binding site, thus contributing to their arrhythmogenic properties.
Keyphrases
  • left ventricular
  • heart failure
  • plasmodium falciparum