In vitro evaluation of ganaplacide/lumefantrine combination against Plasmodium falciparum in a context of artemisinin resistance.
Jeanne ManarancheMarion LaurentRoxane TressieresMichel NguyenMaryam SalimManel OujiThibaud ReyserChinedu O EgwuAnne RobertJean-Michel AugereauFrançoise Benoit-VicalLucie PaloquePublished in: The Journal of antimicrobial chemotherapy (2024)
All these in vitro results evidence that multi-drug resistant parasites currently in circulation in the field might not affect KAF156 efficacy, and are encouraging signs for KAF156 use in a triple ACT to preserve the use of artemisinins for as long as possible.