An extract of phase II and III trials on recent developments in managing neuropathic pain syndromes: diabetic peripheral neuropathy, trigeminal neuralgia, and postherpetic neuralgia.
William C UpshawLenise G SoileauNicholas R StoreyKassady A PerkinsonPatrick M LutherNoah J SpillersChristopher L RobinsonCole MillerShahab AhmadzadehOmar ViswanathSahar ShekoohiAlan D KayePublished in: Expert opinion on emerging drugs (2024)
All the mentioned targets for treatments of NP seem to be promising alternatives for existing treatments that often possess poor side effect profiles for patients. However, gene therapy potentially offers the unique ability to inject a plasmid containing growth factors leading to nerve growth and repair. Because of this, gene therapy appears to be the most intriguing new treatment for NP.
Keyphrases
- gene therapy
- neuropathic pain
- phase ii
- spinal cord
- spinal cord injury
- end stage renal disease
- clinical trial
- ejection fraction
- newly diagnosed
- type diabetes
- escherichia coli
- open label
- peritoneal dialysis
- oxidative stress
- prognostic factors
- patient reported outcomes
- anti inflammatory
- replacement therapy
- phase iii
- patient reported