Gene expression changes in male and female rhesus macaque 60 days after irradiation.

Matthäus MajewskiPatrick OstheimZoya Gluzman-PoltorakVladimir VainsteinLena BasileSimone SchüleMichael HaimerlChristian StroszczynskiMatthias PortMichael Abend

Published in: PloS one (2021)

Sixty days after radiation exposure, we identified (1) sex and cytokine treatment independent transcriptional changes, (2) females with almost twice as much deregulated genes appeared more radio-responsive than males, (3) Panther analysis revealed an association with immunological processes and WNT pathway for both sexes.

Keyphrases

gene expression
dna methylation
genome wide
stem cells
cell proliferation
single cell
transcription factor
radiation induced
combination therapy
oxidative stress
genome wide identification
heat shock
data analysis