Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection.

Yunxian LiuJoseph E EbingerRowann MostafaPetra BuddeJana GajewskiBrian WalkerSandy JoungMin WuManuel BräutigamFranziska HespingElena RupieperAnn-Sophie SchubertHans-Dieter ZuchtJonathan BraunGil Y MelmedKimia SobhaniMoshe ArditiJennifer E Van EykSusan ChengJustyna Fert-Bober

Published in: Journal of translational medicine (2021)

Our results reveal that prior SARS-CoV-2 infection, even in the absence of severe clinical disease, can lead to a broad AAB response that exhibits sex-specific patterns of prevalence and antigen selectivity. Further understanding of the nature of triggered AAB activation among men and women exposed to SARS-CoV-2 will be essential for developing effective interventions against immune-mediated sequelae of COVID-19.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
risk factors
genome wide
physical activity
early onset
single cell
dna methylation
drug induced