Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery.
Aaron EmbryNina S BaggettDavid B HeislerAddison WhiteMaarten F de JongBenjamin L KocsisDiana R TomchickNeal M AltoDon B GammonPublished in: bioRxiv : the preprint server for biology (2024)
was able to rescue all four viruses screened. We discovered that IpaH4 enhances arbovirus replication in both restrictive insect and permissive human cells by directly targeting two novel, evolutionarily conserved antiviral host proteins, SHOC2 and PSMC1, for degradation. Our study establishes bacterial effectors as valuable tools for identifying critical antimicrobial machinery employed by eukaryotic hosts.