Recent advances in metal-catalysed asymmetric sequential double hydrofunctionalization of alkynes.

In recent years, metal-catalysed asymmetric sequential double hydrofunctionalization of alkynes (ASDHA) has emerged as a powerful strategy to construct valuable chiral products in an atom- and pot-economic manner utilizing readily available feedstocks. In this feature article, recent progress made in this field will be overviewed. Attention will be given to the background, substrate scopes, applications, advances and mechanistic investigations of various asymmetric sequential double hydrofunctionalizations of alkynes.