Genetic context modulates aging and degeneration in the murine retina.

Olivia J Marola Michael MacLeanTravis L CossetteCory A DiemlerAmanda A HewesAlaina M ReaganDaniel A SkellyGareth R Howell

Published in: bioRxiv : the preprint server for biology (2024)

Genetic context is a strong determinant of retinal aging, and our multi-omics resource can aid in understanding age-related diseases of the eye and brain. Our investigations identified and validated WSB and NZO mice as improved preclinical models relevant to common retinal neurodegenerative diseases.

Keyphrases

diabetic retinopathy
optic nerve
optical coherence tomography
genome wide
copy number
single cell
white matter
resting state
high fat diet induced
dna methylation
multiple sclerosis
type diabetes
adipose tissue
gene expression
metabolic syndrome
cerebral ischemia