Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library.

Awet Alem TeklemichaelAiko TeshimaAsahi HirataMomoko AkimotoMayumi TaniguchiGholam KhodakaramianTakashi FujimuraFuyuki TokumasuKenji Arakawa Shusaku Mizukami

Published in: Tropical medicine and health (2024)

Secondary metabolites obtained from the actinomycete extracts showed promising antimalarial activity in vitro against 3D7 and Dd2 cell lines of P. falciparum with minimal toxicity. Therefore, secondary metabolites obtained from actinomycete extracts represent an excellent starting point for the development of antimalarial drug leads.

Keyphrases

ms ms
plasmodium falciparum
small molecule
oxidative stress
adverse drug
single cell