Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma.
Marta BuenoAnna PapazoglouEleanor ValenziMauricio RojasRobert LafyatisAna L MoraPublished in: Current rheumatology reports (2020)
Mitochondrial dysfunction and senescence have been linked to the age-related susceptibility to other interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF). SSc is not regarded as an age-related disease but does show a higher incidence of cardiac events, fibrosis, and mortality at older age. We provide an overview of the current status of the role of aging, mitochondrial dysfunction, and senescence in SSc. Further work is needed to validate some of these pathways in SSc and may allow for new therapeutic interventions focused on restoring mitochondrial homeostasis and the targeted removal of chronic-senescent cells.
Keyphrases
- idiopathic pulmonary fibrosis
- interstitial lung disease
- dna damage
- endothelial cells
- current status
- induced apoptosis
- stress induced
- systemic sclerosis
- physical activity
- risk factors
- oxidative stress
- cell cycle arrest
- cell death
- middle aged
- cancer therapy
- rheumatoid arthritis
- type diabetes
- coronary artery disease
- heart failure
- community dwelling
- endoplasmic reticulum stress
- drug delivery