Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.

Sarah GersingThea K SchulzeMatteo CagiadaAmelie SteinFrederick P RothKresten Lindorff-LarsenRasmus Hartmann-Petersen

Published in: Genome biology (2024)

In this study, we identify residues important for GCK metabolic stability and conformational dynamics. These residues could be targeted to modulate GCK activity, and thereby affect glucose homeostasis.

Keyphrases

molecular dynamics
high throughput
molecular dynamics simulations
blood glucose
cancer therapy
adipose tissue
skeletal muscle
weight loss