Ibudilast attenuates alcohol cue-elicited frontostriatal functional connectivity in alcohol use disorder.
Elizabeth M BurnetteLara A RayMichael R IrwinErica N GrodinPublished in: Alcoholism, clinical and experimental research (2021)
Ibudilast's effects on drinking outcomes may be related to the attenuation of functional connectivity in frontostriatal circuits related to reward processing. These results provide an important proof of concept for this novel pharmacotherapy and support the clinical utility of incorporating neuroimaging-and especially functional connectivity-analyses into medication development.