Maternal obesity: sex-specific in utero changes in fetal brain autophagy and mTOR.
Nana MerabovaLierni UgartemendiaAndrea G EdlowClaudia IbarraNune DarbinianGabriel TatevosianLaura GoetzlPublished in: Obesity (Silver Spring, Md.) (2024)
We present novel evidence suggesting that in utero exposure to maternal obesity in humans may significantly affect neurodevelopment, especially in male fetuses, through alterations in normal autophagy molecular mechanisms and with adiponectin as a potential mediator.
Keyphrases
- insulin resistance
- metabolic syndrome
- birth weight
- weight gain
- weight loss
- cell death
- high fat diet induced
- type diabetes
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- pregnancy outcomes
- gestational age
- adipose tissue
- skeletal muscle
- white matter
- body mass index
- multiple sclerosis
- human health
- risk assessment
- subarachnoid hemorrhage
- climate change