Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis.

Zhaoyi PengLingyu BaoJames IbenShouhong WangBingyin ShiYun-Bo Shi

Published in: Cell & bioscience (2024)

Our finding for the first time revealed that the epigenetic enzyme PRMT1 controls mouse enteroendocrine cell development, most likely via inhibition of Neurogenin 3-mediated commitment to EEC lineage. It further suggests a potential role of PRMT1 as a critical transcriptional cofactor in EECs specification and homeostasis to affect metabolism and metabolic diseases.

Keyphrases

single cell
gene expression
cell therapy
dna methylation
cell fate
bone marrow
risk assessment
climate change
human health
binding protein