Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.

Sameera ZiaBrady P HammondMartin ZirngiblAnastasia SizovCharbel S BaakliniSharmistha P PandaMadelene F S HoKelly V LeeApurba MainaliMena K BurrSioned WilliamsAndrew V CaprarielloChristopher PowerThomas SimmenBradley J KerrJason R Plemel

Published in: Molecular neurodegeneration (2022)

Microglia serve multiple roles during demyelination, yet their transcriptomic state resembles other neurodegenerative conditions. The phagocytosis of cellular debris is likely a universal cause for a common neurodegenerative microglial state.

Keyphrases

single cell
inflammatory response
neuropathic pain
lipopolysaccharide induced
rna seq
lps induced
high throughput
spinal cord
spinal cord injury